Understanding Degradation Pathways to Develop Degradation Panels for Extended Characterization

Time: 3:00 pm
day: Conference Day Two


  • Data are presented demonstrating that genome ejection, and not aggregation, is the major degradation pathway for AAVs
  • Routinely measuring free DNA and temperature of genome ejection is vital to understand this degradation pathway
  • A starting point is given for developing a genome ejection assay that can be performed on any real-time PCR instrument